Curr Biol：充分利用注意力可有效缓解疼痛感

亦同，发表文章在国际著名杂志Cell的子刊Current Biology上的一篇报告说明，来进行心理抑制（分心）的方法可以使得痉挛大大减缓，然而这种痉挛减缓大大减缓的震荡并不表现在头部。这项研究课题推测是基于可用高分辨率的骨髓机能性放射超声新科技（fMRI新科技），对人们由于干燥引起的痉挛水平顺利进行研究课题，研究课题揭示，心理抑制无论如何可以在当中枢痉挛检视早期抑制痉挛信号的传入。来自汉堡-埃彭施泰因大学医学院的研究课题者Christian Sprenger对此，这种现象并不仅仅是一种心理现象，而是一种密切关系的神经机制，可以减缓从脊髓上升至人脑高级地带的痉挛信号。

这种震荡涉及到了内源性的化学液体，这种液体产生自人脑，在大大减缓痉挛的过程当中扮演着重要女角。研究课题人员让与则会者分别完成一个直观或者一个很难的记忆性使命，需要他们记住信里的文字内容，同时给与则会者胳膊上施以干燥。顺利进行很难使命的与则会者变得心烦意乱时，他们则会感到较小的痉挛，通过fMRI新科技体现不止这些与则会者的脊髓地带活性变得比较高，fMRI通常是用来校准人脑活性的改变。

Sprenger和他的同事然后多次重复了科学实验，这次他们给予与则会者一种口服-钠洛酮（抗休克的期望口服，可以阻挡类口服的震荡）或者普通的清水注入，表明，相比只注入普通清水的与则会者，可用类口服拮抗剂的与则会者由于注意力混杂，引起的痉挛减缓减缓了40%，因此表明内源性的扮演着重要功用。

研究课题者的推测揭示了无意识可以深入地改变人们的痉挛经历，并且对于临床也有关键性的意义。研究课题者对此，我们的研究课题推测给痉挛结核病疗程提供了知觉行为疗程的方法。（生物谷：T.Shen载入）

doi:10.1016/j.cub.2012.04.006PMC:PMID:

Attention Modulates Spinal Cord Responses to Pain

Christian Sprenger1, , , Falk Eippert1, Jürgen Finsterbusch1, Ulrike Bingel1, 2, Michael Rose1, Christian Büchel1

Reduced pain perception while being distracted from pain is an everyday example of how cognitive processes can interfere with pain perception [ [1], [2], [3], [4] and [5]]. Previous neuroimaging studies showed distraction-related modulations of pain-driven activations in various cortical and subcortical brain regions [ [6], [7], [8], [9], [10] and [11]], but the precise neuronal mechanism underlying this phenomenon is unclear. Using high-resolution functional magnetic resonance imaging of the human cervical spinal cord in combination with thermal pain stimulation and a well-established working memory task [12], we demonstrate that this phenomenon relies on an inhibition of incoming pain signals in the spinal cord. Neuronal responses to painful stimulation in the dorsal horn of the corresponding spinal segment were significantly reduced under high working memory load compared to low working memory load. At the individual level, reductions of neuronal responses in the spinal cord predicted behioral pain reductions. In a subsequent behioral experiment, using the opioid antagonist naloxone in a double-blind crossover design with the same paradigm, we demonstrate a substantial contribution of endogenous opioids to this mechanism. Taken together, our results show that the reduced pain experience during mental distraction is related to a spinal process and involves opioid neurotransmission.